Guillermo A. Ameer
Professor, Department of Biomedical Engineering and Department of Surgery
ScD/PhD (1999) Massachusetts Institute of Technology
The Ameer research group develops regenerative engineering tools that will enable improvements in healthcare and patient quality of life by integrating biomaterials science, engineering, nanotechnology, stem cell science, and medicine. To this end, we design, synthesize, and evaluate advanced functional materials and systems to solve complex medical problems that involve the replacement, repair, or regeneration of tissues and organs. Our laboratory pioneered the development and applications of citrate-based biomaterials (CBBs). CBBs can be engineered to exhibit physical, chemical, and biological functionalities that are suitable to potentially treating injuries and disease conditions that affect blood vessels, bone, ligament, tendon, cartilage, kidney, bladder, skin, pancreas, and liver. We aim to understand and implement fundamental and functional design strategies that enable these materials to control the body's response to injury, treatment, and disease. CBBs have the potential to be an enabling technology for next-generation, patient-specific devices designed to improve the outcome of medical procedures such as wound care, stenting, bypass surgery, bladder augmentation, ligament replacement surgery, neurovascular surgery, and craniofacial reconstruction surgery.
Our current areas of interest include on-demand patient-specific medical devices, regenerative engineering, tissue engineering, wound healing in diabetes, monitoring and controlling the foreign body response, biomaterials and cell-material interactions, and targeted delivery of therapeutic molecules, biomacromolecules, and cells.